Body Composition

Hexarelin

Hexarelin

Most potent GHRP with cardioprotective properties

Research Status: Phase I/II completed; cardiac applications studied Examorelin EP-23905
Mechanism of Action

How it works

Hexarelin is the most potent GH secretagogue peptide, acting on both ghrelin receptors and CD36 scavenger receptors. Its CD36 activity confers unique cardiovascular protective effects independent of GH release.

Areas of Research

What the research explores

In published research, Hexarelin has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.

  • Most potent GH release among all GHSs
  • Unique cardioprotective effects via CD36 receptors
  • Reduces cardiac fibrosis and improves cardiac function
  • Promotes lean muscle mass
  • Anti-obesity effects in animal models
  • Neuroprotective properties
Research Highlight

Hexarelin's activity at CD36 receptors protects against ischemic heart injury and cardiac fibrosis via a mechanism entirely independent of GH release, making it unique among all secretagogues.

Safety Profile

Adverse events & gaps

More significant cortisol and prolactin elevation than Ipamorelin. Desensitization occurs more rapidly with continuous use.



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