Body Composition

GHRP-6

Growth Hormone Releasing Peptide-6

The original growth hormone secretagogue

Research Status: Extensive preclinical; Phase I completed His-DTrp-Ala-Trp-DPhe-Lys-NH2
Mechanism of Action

How it works

GHRP-6 stimulates the ghrelin receptor to release GH from the pituitary. It significantly increases ghrelin-like activity, resulting in pronounced hunger stimulation alongside GH secretion.

Areas of Research

What the research explores

In published research, GHRP-6 has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.

  • Strong GH and IGF-1 elevation
  • Significantly increases appetite (caloric surplus support)
  • Promotes muscle mass in hypocaloric states
  • Gastroprotective properties
  • Cardioprotective in ischemia models
  • Anti-inflammatory via inhibition of TNF-alpha
Research Highlight

GHRP-6 was the first synthetic GHS and has generated over 40 years of research data. Its appetite stimulation makes it distinct for lean mass research.

Safety Profile

Adverse events & gaps

Marked increase in hunger, potential cortisol elevation, some water retention. Long history of research.



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