Body Composition

Ipamorelin

Ipamorelin

The most selective GH secretagogue

Research Status: Preclinical + Phase I completed NNC 26-0161
Mechanism of Action

How it works

Ipamorelin selectively agonizes ghrelin receptors (GHS-R1a) on the pituitary to stimulate GH release without significantly affecting cortisol, prolactin, or ACTH. This high selectivity gives it a uniquely clean safety profile.

Areas of Research

What the research explores

In published research, Ipamorelin has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.

  • Stimulates selective, clean GH release
  • Promotes fat loss without muscle catabolism
  • Improves lean body composition
  • Enhances sleep architecture and recovery
  • Minimal effects on cortisol and prolactin
  • Synergistic with GHRH analogs like CJC-1295
Research Highlight

Compared to GHRP-2 and GHRP-6, Ipamorelin shows equivalent GH release with virtually no cortisol or prolactin elevation, making it the preferred research secretagogue.

Safety Profile

Adverse events & gaps

Considered the most favorable safety profile among GHSs. Minimal reported side effects.



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