MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
The exercise-mimetic mitochondrial peptide
How it works
MOTS-c translocates from mitochondria to the nucleus during metabolic stress, where it directly activates AMPK and regulates nuclear gene expression for metabolic adaptation. It mimics beneficial effects of exercise on glucose metabolism.
What the research explores
In published research, MOTS-c has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.
- Activates AMPK pathways that mimic exercise adaptation
- Improves insulin sensitivity and glucose utilization
- Enhances mitochondrial function and biogenesis
- Reduces age-related metabolic decline
- Promotes longevity via metabolic reprogramming
- Reduces inflammation associated with metabolic dysfunction
MOTS-c is dubbed the "exercise peptide" because it activates the same metabolic pathways engaged during physical exercise, with declining levels in elderly subjects correlating with metabolic disease risk.
Adverse events & gaps
No adverse events in animal studies. Human data emerging.
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