Humanin
Humanin
Mitochondrial peptide protecting against neurodegeneration and aging
How it works
Humanin is encoded in the mitochondrial 16S rRNA gene and signals through IL-6 family receptors (gp130, CNTFR, WSX-1). It inhibits BAX-mediated apoptosis, improves insulin sensitivity, and declines with age in humans.
What the research explores
In published research, Humanin has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.
- Potent neuroprotection against amyloid beta toxicity
- Improves insulin sensitivity and glucose metabolism
- Reduces oxidative stress and mitochondrial damage
- Levels correlate inversely with aging and disease
- Cardioprotective in ischemia/reperfusion models
- Enhances cognitive function in Alzheimer's models
Humanin levels in humans decline significantly with age, and centenarians have measurably higher circulating Humanin than age-matched controls, suggesting it as a longevity biomarker and potential intervention target.
Adverse events & gaps
No adverse events in animal models. Human safety data limited but emerging.
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