Sexual Health

Melanotan II

Melanotan II

Melanocortin agonist with tanning, libido, and metabolic effects

Research Status: Extensive research; no regulatory approval (non-selective profile) MT-II MT2 MT-2 Melanotan 2
Mechanism of Action

How it works

Melanotan II is a non-selective melanocortin agonist (MC1R through MC5R). MC1R activation produces melanogenesis (tanning), MC3R/MC4R activation in the hypothalamus affects sexual arousal and appetite suppression, and MC4R in the brainstem affects erection.

Areas of Research

What the research explores

In published research, Melanotan II has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.

  • Stimulates melanogenesis (natural skin darkening)
  • UV-protective effect via increased melanin
  • Strong libido enhancement and arousal
  • Appetite suppression and metabolic effects
  • Erectile and arousal effects in both sexes
  • Studied for compulsive eating disorders
Research Highlight

Melanotan II was the subject of clinical trials at the University of Arizona in the 1990s, showing tanning effects at doses 10x lower than UV exposure. Its non-selectivity led to PT-141 development.

Safety Profile

Adverse events & gaps

Significant side effects: nausea, flushing, spontaneous erection, increased moles/nevi. Long-term safety unknown. Not approved.



Stay Informed on
Peptide Research

Research summaries, newly documented peptides, and clinical trial updates delivered to your inbox.

No spam. Unsubscribe at any time.