Sexual Health

Kisspeptin

Kisspeptin-10

Master upstream regulator of the reproductive hormone axis

Research Status: Active clinical research Metastin KISS1 Kisspeptin-10
Mechanism of Action

How it works

Kisspeptin binds the KISS1R (GPR54) receptor on hypothalamic neurons to trigger release of GnRH, the signal that drives LH and FSH and the entire reproductive-hormone cascade. It sits at the top of this axis.

Areas of Research

What the research explores

In published research, Kisspeptin has been studied in connection with the following. These describe findings reported in the literature — not approved uses, claims, or outcomes to expect.

  • Stimulates the natural GnRH/LH/FSH cascade
  • Studied in fertility and hypothalamic amenorrhea research
  • Investigated for sexual and emotional processing
  • Probes reproductive-axis function in research
  • Physiologic, upstream mechanism
Research Highlight

Imperial College London studies reported that kisspeptin administration enhanced both sexual and emotional brain-processing responses, alongside its established role in stimulating reproductive hormones.

Safety Profile

Adverse events & gaps

Well tolerated in research settings as a physiologic signaling peptide. Profile still being characterized.



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